diff --git a/soh/src/overlays/actors/ovl_En_Ik/z_en_ik.c b/soh/src/overlays/actors/ovl_En_Ik/z_en_ik.c
index 80259df9a..4f9a898f5 100644
--- a/soh/src/overlays/actors/ovl_En_Ik/z_en_ik.c
+++ b/soh/src/overlays/actors/ovl_En_Ik/z_en_ik.c
@@ -656,7 +656,9 @@ void func_80A75A38(EnIk* this, PlayState* play) {
             }
             if (this->unk_2F9 == 0) {
                 Item_DropCollectibleRandom(play, &this->actor, &this->actor.world.pos, 0xB0);
-                if (this->switchFlags != 0xFF) {
+                // Don't set flag when Iron Knuckle is spawned by Enemy Rando.
+                // Instead Iron Knuckles rely on the "clear room" flag when Enemy Rando is on.
+                if (this->switchFlags != 0xFF && !CVar_GetS32("gRandomizedEnemies",0)) {
                     Flags_SetSwitch(play, this->switchFlags);
                 }
                 Actor_Kill(&this->actor);
diff --git a/soh/src/overlays/actors/ovl_En_Rd/z_en_rd.c b/soh/src/overlays/actors/ovl_En_Rd/z_en_rd.c
index d01d3c4e7..7aa37cedb 100644
--- a/soh/src/overlays/actors/ovl_En_Rd/z_en_rd.c
+++ b/soh/src/overlays/actors/ovl_En_Rd/z_en_rd.c
@@ -663,7 +663,8 @@ void func_80AE3C98(EnRd* this, PlayState* play) {
 
     if (SkelAnime_Update(&this->skelAnime)) {
         if (this->unk_30C == 0) {
-            if (!Flags_GetSwitch(play, this->unk_312 & 0x7F)) {
+            // Don't set this flag in Enemy Rando as it can overlap with other objects using the same flag.
+            if (!Flags_GetSwitch(play, this->unk_312 & 0x7F) && !CVar_GetS32("gRandomizedEnemies", 0)) {
                 Flags_SetSwitch(play, this->unk_312 & 0x7F);
             }
             if (this->unk_314 != 0) {